Q fever: Coxiella burnetii
Remember, phase I = persistent localized: phase II = acute
Endocarditis is not the only manifestation of persistent infection. Look for bone and joint infections and endovascular infections in pts at risk. 🤔Think Q fever if +antiphospholipid, +antimitochindrial, +anti-smooth in pts w/ no autoimmune d/o.
Hydroxychloroquine alkalinizes 🧪 Coxiella burnetii 🦠replication vacuole and increases bactericidal activity of doxycycline